日本生薬学会　論文賞

日本生薬学会　JNM・生薬学雑誌　論文賞　一覧

令和5年度（令和6年3月8日決定）

1) Takashi Ogihara, Masato Kagawa, Rintarou Yamanaka, Satoshi Imai, Kotaro Itohara, Daiki Hira, Shunsaku Nakagawa, Atsushi Yonezawa, Michiho Ito, Takayuki Nakagawa, Tomohiro Terada, Kazuo Matsubara. Preparation and pharmaceutical properties of Hangeshashinto oral ointment and its safety and efficacy in Syrian hamsters with 5‐fluorouracil‐induced oral mucositis. Journal of Natural Medicines 77(1), 53-63 (2023).

2) Yoshitomi Kudo, Hirokazu Ando, Ai Kaneda, Honoka Ito, Kazuki Umemoto, Si-ran Ni, Masayuki Mikage, Yohei Sasaki. Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content. Journal of Natural Medicines 77(2), 327-342 (2023).

3) Yan Liu, Itsuki Nose, Kazuyoshi Terasaka, Tsukasa Fueki, Toshiaki Makino. Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber. Journal of Natural Medicines 77(4), 761-773 (2023).

JNM Award 2012-2023 Announcement (Springer)

令和4年度（令和5年2月24日決定）

1) Qundong Liu, Shu Zhu, Shigeki Hayashi, Osamu Iida, Akihito Takano, Katsunori Miyake, Suchada Sukrong, Mangestuti Agil, Indira Balachandran, Norio Nakamura, Nobuo Kawahara, Katsuko Komatsu: Discrimination of Curcuma species from Asia using intron length polymorphism markers in genes encoding diketide-CoA synthase and curcumin synthase. J Nat Med (2022) 76: 69–86.

2) Taishi Kondo, Tomoaki Ishida, Ke Ye, Marin Muraguchi, Yohei Tanimura, Masato Yoshida, Kan’ichiro Ishiuchi, Tomoki Abe, Takeshi Nikawa, Keisuke Hagihara, Hidetoshi Hayashi, Toshiaki Makino: Suppressive effects of processed aconite root on dexamethasone-induced muscle ring fingerprotein-1 expression and its active ingredients. J Nat Med (2022) 76: 594–604.

3) Naoko Yoshimoto, Takashi Asano, Ayuna Kisanuki, Chihiro Kanno, Machiko Asanuma, Mami Yamazaki, Isao Fujii, Kazuki Saito: The ability of callus tissues induced from three Allium plants to accumulate health-beneficial natural products, S-alk(en)ylcysteine sulfoxides. J Nat Med (2022) 76: 803–810.

令和3年度（令和4年2月28日決定）

1) Yoshitomi Kudo, Hirokazu Ando, Yohei Sasaki: Quality evaluation of Angelicae acutilobae radix: individual differences and localization of (Z)-ligustilide in Angelica acutiloba root. J Nat Med (2021) 75: 1-10.

2) Kazuki Okoshi, Yoshinori Uekusa, Yuji Narukawa, Fumiyuki Kiuchi: Solubility enhancement of berberine–baicalin complex by the constituents of Gardenia Fruit. J Nat Med (2021) 75: 76-83.

3) Tatsuya Shirahata, Hiroshi Ishikawa, Teruhisa Kudo, Yumiko Takada, Azusa Hoshino, Yui Taga, Yusaku Minakuchi, Tomoko Hasegawa, Rina Horiguchi, Takehiro Hirayama, Takahiro Konishi, Hiroaki Takemoto, Noriko Sato, Masako Aragane, Tetsuro Oikawa, Hiroshi Odaguchi, Toshihiko Hanawa, Eiichi Kodaira, Tatsuo Fukuda, Yoshinori Kobayashi: Metabolic fingerprinting for discrimination of DNA-authenticated Atractylodes plants using 1H NMR spectroscopy. J Nat Med (2021) 75: 475-488.

令和2年度（令和3年2月15日決定）

1) Rui Tang, Atsushi Kimishima, Ryosuke Ishida, Andi Setiawan, Masayoshi Arai: Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation. J Nat Med (2020) 74: 153-158.

2) Jianbo Wu, Souichi Nakashima, Marina Shigyo, Mutsumi Yamasaki, Sumire Ikuno, Aoi Morikawa, Shigehiko Takegami, Seikou Nakamura, Atsuko Konishi, Tatsuya Kitade, Hisashi Matsuda: Antihypertensive constituents in Sanoshashinto. J Nat Med (2020) 74: 421-433.

3) Tsukasa Fueki, Koichiro Tanaka, Kunihiko Obara, Ryudo Kawahara, Takao Namiki, Toshiaki Makino: The acrid raphides in tuberous root of Pinellia ternata have lipophilic character and are specifically denatured by ginger extract. J Nat Med (2020) 74: 722-731.

令和元年度（令和2年2月28日決定）

1) Toshio Kaneda, Misaki Matsumoto, Yayoi Sotozono, Satoshi Fukami, Alfarius Eko Nugroho, Yusuke Hirasawa, Hadi A. Hamid A, Hiroshi Morita: Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both β-catenin and c-Raf-MEK1-ERK signaling axis, J Nat Med (2019) 73: 47-58.

2) Ken-ichi Nakashima, Junko Tomida, Takao Hirai,Yoshiaki Kawamura, Makoto Inoue: Sesquiterpenes with new carbon skeletons from the basidiomycete Phlebia tremellosa, J Nat Med (2019) 73: 480-486.

3) Kazufumi Toume, Zhiyan Hou, Huanhuan Yu, Mitsuru Kato, Miki Maesaka, Yanjing Bai, Shiho Hanazawa, Yuewei Ge, Tsugunobu Andoh, Katsuko Komatsu: Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula “Goshajinkigan”, J Nat Med (2019) 73: 761-768.

平成31年度（平成31年2月25日決定）

1) Alfarius Eko Nugroho, Akiyo Hashimoto, Chin-Piow Wong, Hiromasa Yokoe, Masayoshi Tsubuki, Toshio Kaneda, A. Hamid A. Hadi, Hiroshi Morita: Ceramicines M-P from Chisocheton ceramicus: isolation and structure-activity relationship study, J Nat Med (2018) 72: 64-72.

2) Risako Kon, Miho Yamamura, Yukari Matsunaga, Hiroshi Kimura, Moe Minami, Saki Kato, Nobutomo Ikarashi, Kiyoshi Sugiyama: Laxative effect of repeated Daiokanzoto is attributable to decrease in aquaporin-3 expression in the colon, J Nat Med (2018) 72: 493-502.

3) Shu Zhu, Aimi Shirakawa, Yanhong Shi, Xiaoli Yu, Takayuki Tamura, Naotoshi Shibahara, Kayo Yoshimatsu, Katsuko Komatsu: Impact of different post-harvest processing methods on the chemical compositions of peony root, J Nat Med (2018) 72: 757-767.

平成30年度（平成30年2月25日決定）

1) Amit Rai, Hidetaka Kamochi, Hideyuki Suzuki, Michimi Nakamura, Hiroki Takahashi, Tomoki Hatada, Kazuki Saito, Mami Yamazaki: De novo transcriptome assembly and characterization of nine tissues of Lonicera japonica to identify potential candidate genes involved in chlorogenic acid, luteolosides, and secoiridoid biosynthesis pathways, J Nat Med (2017) 71: 1-15.

2) Shunsuke Nakamori, Jun Takahashi, Sumiko Hyuga, Toshiko Tanaka-Kagawa, Hideto Jinno, Masashi Hyuga, Takashi Hakamatsuka, Hiroshi Odaguchi, Yukihiro Goda, Toshihiko Hanawa, Yoshinori Kobayashi: Ephedra Herb extract activates/desensitizes transient receptor potential vanilloid 1 and reduces capsaicin-induced pain, J Nat Med (2017) 71:105-113.

3) Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, Shinsuke Hisaka, Sayaka Masada, Masato Homma, Takashi Hakamatsuka: Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan, J Nat Med (2017) 71:711-722.

平成29年度（平成29年2月26日決定）

1) Emiko Iwaoka, Shenglan Wang, Nobuyuki Matsuyoshi, Yoko Kogure, Shunji Aoki, Satoshi Yamamoto, Koichi Noguchi, Yi Dai: Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels, J Nat Med (2016) 70: 1-7.
2)Yuki Kawahara, Tatsuro Hoshino, Hidetaka Morimoto, Tomofumi Shinizu, Yuji Narukawa, Hiroyuki Fuchino, Nobuo Kawahara, Fumiyuki Kiuchi: LC-MS-based quantification method for Achyranthes root saponins, J Nat Med (2016) 70:102-106.
3) Taketo Okada, Farit Mochamad Afendi, Mami Yamazaki, Kaori Nakahashi Chida, Makoto Suzuki, Rika Kawai, Miyuki Kim, Takao Namiki, Shigehiko Kanaya, Kazuki Saito: Informatics framework of traditional Sino-Japanese medicine (Kampo) unveiled by factor analysis, J Nat Med (2016) 70:107-114.

平成28年度（平成28年3月1日決定）

1) Shu Zhu, Xiaoli Yu, Yuqiu Wu, Fumio Shiraishi, Nobuo Kawahara, Katsuko Komatsu: Genetic and chemical characterization of white and red peony root derived from Paeonia lactiflora. Journal of Natural Medicines 69(1), 35-45 (2015). (Open access article)
2) Noriko Kaifuchi, Yuji Omiya, Hirotaka Kushida, Miwako Fukuake, Hiroaki Nishimura: Effects of shakuyakukanzoto and its absorbed components on twitch contractions induced by physiological Ca²⁺ release in rat skeletal muscle. Journal of Natural Medicines 69(3), 287-295 (2015). (Open access article)
3) Toshio Morikawa, Kiyofumi Ninomiya, Junji Akaki, Namiko Kakihara, Hiroyuki Kuramoto, Yurie Matsumoto, Takao Hayakawa, Osamu Muraoka, Li-Bo Wang, Li-Jun Wu, Seikou Nakamura, Masayuki Yoshikawa, Hisashi Mtsuda: Dipeptidyl peptidase-IV inhibitory activity of dimeric dihydrochalcone glycosides from flowers of Helichrysum arenarium. Journal of Natural Medicines 69(4), 494-506 (2015). (Open access article)

平成27年度（平成27年2月19日決定）

1)Yukie Kumeta, Takuro Maruyama, Hiroshi Asama, Yutaka Yamamoto, Takashi Hakamatsuka, Yukihiro Goda: Species identification of Asini Corii Collas (donkey glue) by PCR amplification of cytochrome b gene. Journal of Natural Medicines 68(1), 181-185 (2014).
2)Yuko Kiren, Alfarius Eko Nugroho, Yusuke Hirasawa, Osamu Shirota, Myrzaim Bekenova, Narbekov Omorbay Narbekovich, Marina Shapilova, Hiromichi Maeno, Hiroshi Morita:　Mumic acids A–E: new diterpenoids from mumiyo. Journal of Natural Medicines 68(1), 199-205 (2014).
3)Toshiaki Makino, Yusaku Shiraki, Hajime Mizukami: Interaction of gypsum and the rhizome of Anemarrhena asphodeloides plays an important role in anti-allergic effects of byakkokakeishito in mice. Journal of Natural Medicines 68(3), 505-512 (2014).

平成26年度

1) Jia, X.-H., Wang, C.-Q., Liu, J.-H., Li, X.-W., Wang, X., Shang, M.-Y., Cai, S.-Q., Zhu, S., Komatsu, K.
Comparative studies of saponins in 1-3-year-old main roots, fibrous roots, and rhizomes of Panax notoginseng, and identification of different parts and growth-year samples. Journal of Natural Medicines 67 (2), 339-349 (2013).
2) Sekiya, M., Kiyohara, H., Maruyama, H., Yabe, T., Yamada, H.
Modulation of chemokine expression on intestinal epithelial cells by Kampo (traditional Japanese herbal) medicine, Hochuekkito, and its active ingredients. Journal of Natural Medicines 67 (3), 626-635 (2013).
3) Zaima, K., Koga, I., Iwasawa, N., Hosoya, T., Hirasawa, Y., Kaneda, T., Ismail, I. S., Lajis, N. H., Morita, H.
Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma. Journal of Natural Medicines 67 (1), 9-16 (2013).

平成25年度

1) Kiyohara, H., Ichino, C., Kawamura, Y., Nagai, T., Sato, N., Yamada, H.
Patchouli alcohol: in vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth. Journal of Natural Medicines 66(1), 55-61 (2012).
2) Bai, F., Makino, T., Ono, T., Mizukami, H.
Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway. Journal of Natural Medicines 66(4), 583-590 (2012).
3) 渕野裕之、菱田敦之、赤木謙一、木内文之、川原信夫
LC-NMR/MSを用いた生薬の品質評価法に関する研究(1)―生薬ゴシツの栽培および加工調製法について―　生薬学雑誌、66(1), 1-16 (2012).

平成24年度

1) Arai, M., Hayashi, A., Sobou, M., Ichida, S., Kawachi, T., Kotokum N., Kobayashi, M.
Anti-angiogenic effect of triterpenoidal saponins from Polygala senega. Journal of Natural Medicines 65 (1), 149-156 (2011).
2) Nogami, A., Sakata, Y., Uchida, N., Yamaguchi, K., Kawasaki, C., Shindo, T., Kubota, K., Katsurabayashi, S., Takasaki< S., Mishima, K., Nishimura, R., Fujiwara, M., Iwasaki, K..
Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia. Journal of Natural Medicines 65 (2), 275-281 (2011).
3) 山口茂治、安部正太郎、土田貴志、小山忠一、石黒千秋、村口昌三、許　秀海、胡　志強、馮　焔、李　金剛、浅間宏志、佐々木博　
薬用植物栽培における使用農薬の実態調査（第１報）中国産チンピの使用農薬　生薬学雑誌、65(1), 10-17 (2011).

平成23年度

1) Hasada, K., Yoshida, T., Yamazaki, T., Sugimoto, N., Nishimura, T., Nagatsu, A., Mizukami,H. Quantitative determination of atractylon in Atractylodis Rhizoma and Atractylodis Lanceae Rhizoma by 1H-NMR spectroscopy. Journal of Natural Medicines 64 (2), 161-166 (2010).
2) Asami, A., Shimada, T., Mizuhara, Y., Asano, T., Takeda, S., Aburada, T., Miyamoto, K., Aburada, M., Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I).
Journal of Natural Medicines 64 (3), 281-287 (2010).

平成22年度

1) Sumiyoshi, M., Hayashi, T. Kimuta, T., Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced phtoaging in melanin-processing hairless mice.
Journal of Natural Medicnes, 63(2), 130-126 (2009).
2) Zhu, S., Sugiyama, R., Batkhuu, J., Sanchir, C., Zou, K., Komatsu, K., Survey of Glycyrrhizae Radix resources in Mogolia: chemical assessment of the undergraound part of Glycyrrhiza uralensis and comparison with Chinese Glycurrhizae Radix.
Journal of Natural Medicnes, 63(2), 137-146 (2009).
3) Yamasaki, K., Tagami, T., Kawaguchi, M., Okihashi, M., Takatori, S., Sakagami, Y., Sekita, S., Satake, M., Simple and rapid analysis of aristolochioc acid contained in crude drugs and Kampo formulations with solid-phase extraction and HPLC phtodiode-array detection.
Journal of Natural Medicnes, 63(4), 451-458 (2009).

平成21年度

1) H. Takemoto, M. Ito, T. Shiraki, T. Yagura, and G. Honda, Sedative effects of vapor inhalation of agarwood oil and spikenard extract and identification of their active components.
Journal of Natural Medicines 62 (1), 41-46 (2008).
2) K. Komatsu, Y. Sasaki, K. Tanaka, Y. Kuba, H. Fushimi, and S. Q. Cai, Morphological, genetic, and chemical polymorphism of Curcuma kwangsiensis.
Journal of Natural Medicines 62 (4), 413-422 (2008).
3) T. Nakamori, M. Taniguchi, M. Shibano, N. H. Wang, and K. Baba, Chemical studies on the root of Heracleum candicans W ALL..
Journal of Natural Medicines, 62 (4), 403-412 (2008).

平成20年度

1) Suna, H., Aoki, S., Setiawan, A., Kobayashi, M., Crambescidin 800, a pentacyclic guanidine alkaloid, protects a mouse hippocampal cell line against glutamate-induced oxidative stress.
Journal of Natural Medicines, 61 (3), 288-295 (2007).
2) Kitamura, C., Nagoe, T., Sri Prana, M., Agusta, A., Ohashi, K., Shibuya, H., Comparison of Curcuma sp. in Yakushima with C. aeruginosa and C. zedoaria in Java by trnK gene sequence, RAPD pattern and essential oil component.
Journal of Natural Medicines, 61 (3), 239-243(2007).
3) Ichiki, H. , Takeda O., Sakakibara I., Terabayashi S., Takeda S., Sasaki H., Inhibitory effects of compounds from Anemarrhenae Rhizoma on α-glucosidase and aldose reductase and its contents by drying conditions.
Journal of Natural Medicines 61(2) 146-153 (2007).

平成19年度

1) 中村理恵、牧野文昌、遠藤雄一、榊原巌、寺林進、竹田秀一、佐々木博
鉱物生薬の解明研究（１）　麻杏甘石湯の石膏が湯液に及ぼす影響
生薬学雑誌、60(2), 59-67 (2006).
2) Kitajima, M., Misawa, K., Kogure, N., Said, I. M., Horie, S., Hatori, Y., Maruyama, T., Takayama, H., A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malayasian Mitragyna speciosa and its opioid agonistic activity.
Journal of Natural Medicines, 60 (1), 28-35 (2006).
3) Nakamura, T., Komai, N., Isogami, K., Ueno, K., Ikegami, F., Ono, S., Yano, S., Memory adn learning-enhancing effect of Daikenchuto, a traditional Japanese herbal medicine, in mice.
Journal of Natural Medicines, 60(1), 64-67 (2006).

平成18年度

1) 堀由美子、若松雪絵、大枝稔、水井佳代子、福村基徳、平井康昭、根本幸夫、鳥居塚和生、伊田喜光
ショウキョウとカンキョウによるスルホン化誘導体
Natural Medicnes, 59(5), 229-236 (2005).
2) 安食菜穂子、川原信夫、合田幸広
味認識装置による漢方処方の味の評価に関する研究（第１報）
Naturel Medicines, 59(4), 164-170 (2005).

平成17年度

1)滝　昌則、松葉知浩、福地幹男、油田正樹、岡田　稔、「北海道と茨城県で栽培したハナトリカブト(Aconitumcarmichaeli DEBX.)の生育及び塊根成分の季節変動比較」、Natural Medicines 58(2), 55-63(2004).
2)Ryota Tsuchihashi, Masafumi Okawa, Toshihiro Nohara, Hikaru Okabe, Junei Kinjo,「Soy Isoflavone Metabolites Isolated from Human Urine」, Natural Medicines 58(2), 71-75(2004).
3)久保道徳、藤田　忠、西村幸容、得永雅士、松田秀秋、我藤　雄、友廣教道、佐々木勝昭、宇宮直樹、「柑橘類のフラバノン配糖体含量と抗アレルギー作用の季節的推移」, Natural Medicines 58(6), 284-294(2004).

平成16年度

1) 中村理恵、加瀬義夫、橋本和則、榊原巌、油田正樹甘草の抗潰瘍作用本体の解明 Natural Medicines, 57 (5), 172-177 (2003).
2) Minami M., Hosokawa K., Mia M. W., Sakai E., Satake M., Kondo S., Oka K., Koga-Ban Y., Kayano T., Tanaka H., Shibata T. Morphological, chemical and molecular biological comparison among Artemisia capillaris , A. japonica and their natural hybrids Natural Medicines 57 (1), 1-6 (2003).
3) Yani Hu, Ting Guo Kang, Zhongzhen Zhao, Studies on Microscopic Identification of Animal Drugs' Remnant Hair (1)Identification of Cordyceps sinensis and Its Counterfeits Natural Medicines 57(5), 163-171 (2003).

平成15年度

1) 橋本昌夫、芝由美、中村考志、桑原由佳里、西博行「生薬の無機化学的品質評価に関する研究（1）鉱物生薬のICP発光分析法に関する品質評価」、Vol.56(6), 239-246(2002).
橋本昌夫、芝由美、中村考志、西博行「生薬の無機化学的品質評価に関する研究（2）鉱物生薬からの無機成分の溶出挙動」、Vol.56(6), 247-254(2002).
2) 滝昌則、寺林進、松葉知浩、佐々木博、福地幹男、岡田稔「中国及び日本における「ブシ」の品質評価」、Vol.56(5), 163-172(2002).
3) Hiromichi Matuura, Manabu Udayama, Rumiko Dokan, Rhoji Kasai, Kazuo Yamasaki, Osamu Tanaka, [Identification and quantification of 20 (S)-protopanaxatriol and its 20S, 2４S-epoxide in human urine with the treatment of alkakine cleavage after the ingestion of sanchi ginseng, the roots of Panax notoginseng （三七人参）」、Vol. 56(2), 34-39(2002）.

平成14年度

1) 宮本弘子、池田孔己、武田修己、久保正良、樋口正視、佐々木博、岡田稔「統計学的手法を用いた生薬選定法の検討－抗炎症作用を有する大黄の検索－」Natural Medicines 55 (4) 159-164 (2001).
2) Miwa Takeuchi, Shoichi Suzuki, Hiroharu Fujino, Munehisa Arisawa, Hiroshi Kohda, Natural Medicines 55 (1) 17-22 (2001).
Miwa Takeuchi, Yasushi Suzuki, Shoichi Suzuki, Hiroharu Fujino, Masao Yoshizaki, Hiroshi Kohda, Natural Medicines 55(5) 225-230 (2001).
Miwa Takeuchi, Yasushi Suzuki, Shoichi Suzuki, Hiroharu Fujino, Munehisa Arisawa, Hiroshi Kohda, Natural Medicines 55(5) 231-234 (2001).
「Evaluation of Valeriana Plants and Their Improvement for Crude Drug Production」
3) 松田秀秋、吉川正人、井戸康子、雨宮勉、久保道徳「呉茱萸によるインドメタシン含有軟膏の抗炎症・鎮痛効果の増強作用 (Natural　Medicines 55 (5) 235-242 (2001).